Volume 1, Number 2, December 2000

Valsartan and the renin-angiotensin-aldosterone system: blood pressure control and beyond
Björn Dahlöf

AT₁-receptor blockade with valsartan lowers blood pressure, is well-tolerated, reverses target organ damage and promises benefits beyond BP lowering. AT₁-receptor blockade may well become the leading route of tackling hypertension and associated cardiovascular problems. Valsartan can prevent remodelling, microalbuminuria and atherosclerosis, and improve endothelial dysfunction. A series of large studies comprising more than 35,000 patients, including VALUE,²⁰ Val-HeFT,²¹ VALIANT²² and ABCD-2V, will in the near future provide important data on the effect of valsartan on mortality and morbidity.

JRAAS 2000;1:14-16.

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