Volume 2, Number 2, June 2001

Valsartan and candesartan can inhibit deteriorating effects of angiotensin II on coronary endothelial function - Article includes book review
Harald Seeger, Caroline Lippert, Diethelm Wallwiener, Alfred O Mueck

The angiotensin II (Ang II) AT₁-receptor antagonists, valsartan and candesartan, were compared with regard to their effect on Ang II-mediated changes in parameters of coronary endothelial function. Ang II (10 μM) induced increased concentrations of the vasoconstrictor endothelin, the procoagulatory substance plasminogen-activator-inhibitor-1 (PAI-1) and the precursor of the matrix-metalloproteinase 1 (MMP-1) in endothelial cell cultures from human coronary arteries. These increases were completely prevented by the addition of 10 μM valsartan or candesartan and partially by the addition of lower concentrations of these drugs, i.e. 1 μM and 0.1 μM. No significant difference between the effect of the two AT₁-receptor antagonists was observed.
These results suggest that AT₁-receptor antagonists not only can reduce blood pressure by blocking the action of Ang II, but might also contribute to the prevention of atherogenesis and plaque instability.

JRAAS 2001;2:141-143.

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