Volume 2, Number 4, December 2001

Bioactive angiotensin peptides: focus on angiotensin IV
Tomris Mustafa, Joo Hyung Lee, Siew Yeen Chai, Anthony L Albiston, Sharon G McDowall, Frederick AO Mendelsohn

Angiotensin II (Ang II) is widely regarded as the major active peptide of the renin-angiotensin system (RAS), exerting effects on the cardiovascular system and on fluid and electrolyte homeostasis, including neural and long-term trophic effects. However, recent studies indicate that other angiotensin peptides such as angiotensin III (Ang III), Ang II (1-7) and angiotensin IV (Ang IV), may also have specific actions. Ang IV binds to a specific binding site and may be involved in memory retention, neuronal development and cardiovascular actions. It now appears, that the RAS is more complex than previously thought and is capable of generating multiple, bioactive peptides that elicit numerous diverse actions.

JRAAS 2001;2:205-210.

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