Volume 2, Number 4, December 2001

Intracellular angiotensin II: from myth to reality?
Catalin M Filipeanu, Robert H Henning, S Adriaan Nelemans, Dick de Zeeuw

Recent studies show that angiotensin II (Ang II) has complex actions from within the cell, possibly via intracellular receptors that are pharmacologically different from the typical plasma membrane angiotensin receptors. Specific effects of intracellular Ang II have been described ranging from modulation of gap junctions to effects on cell growth, MAP kinase and calcium signalling. This paper summarises the evidence for this system to be acknowledged as a new entity separate from the circulating or local renin-angiotensin-aldosterone system (RAAS), by reviewing intracellular production of Ang II, the pharmacology and possible origin of intracellular angiotensin receptors and the signal transduction pathways involved in its functional effects.

JRAAS 2001;2:219-226.

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