Volume 3, Number 3, September 2002

Antiproteinuric effect of candesartan cilexetil in patients with chronic glomerulonephritis
Kiyoshi Kurokawa, Keishi Abe, Takao Saruta, Masaaki Arakawa, Ryuichi Kikkawa, Naohiko Ueda, Kaoru Onoyama, Kimio Tomita, Nobuya Ogawa

A prospective, randomised, double-blind, parallel-group, dose-response trial was conducted to investigate the antiproteinuric effect of candesartan cilexetil, the angiotensin II type 1 receptor blocker, in patients with chronic glomerulonephritis. Patients (n=280) were treated for 12 weeks with candesartan cilexetil 2, 4, or 8 mg given orally once-daily (o.d.). The improvement in urinary protein excretion observed at the end of the treatment period was 15.9% in the 2 mg group, 25.6% in the 4 mg group, and 34.6% in the 8 mg group, respectively, showing a clear dose-response (2 mg <4 mg <8 mg; p=0.003). The mean reduction in urinary protein excretion was 11.3% in the 2 mg group, 26.3% in the 4 mg group, and 26.0% in the 8 mg group, showing a dose-response pattern, in that the effect of 4 mg and 8 mg was greater than that of 2 mg (2 mg <4 mg ≈8 mg; p=0.010). As the observed reduction in urinary protein excretion failed to correlate with changes in mean blood pressure, it could not be attributed to the antihypertensive effect of the study drug alone. This suggests that candesartan cilexetil, 4–8 mg o.d., has antiproteinuric effects in patients with chronic glomerulonephritis.

JRAAS 2002;3:167-175.

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